Barclays Premier League leaders Chelsea take on one of their main championship rivals in this week's Saturday lunchtime game, live on BT Sport.
Arsenal make the trip across the capital to Stamford Bridge for the lunchtime kick-off, with the third-place side looking to close the gap at the top to one point.
Arsène Wenger's side are currently four points behind Chelsea with a game in hand, meaning three points in Saturday's London derby could throw the title race wide open.
Second-placed Liverpool have the same record as Arsenal - 62 points from 29 games, but with a superior goal difference - while Manchester City are a further two points back, with three games in hand on Chelsea.
As such, any one of four teams could get their hands on the Barclays Premier League crown come May.
Chelsea suffered a major setback last Saturday, losing 1-0 away at Aston Villa, ending a run of three consecutive Barclays Premier League wins.
However the Blues have since enjoyed a morale-boosting win against Galatasaray in the UEFA Champions League - one which puts them through to the quarter-final stage.
As with the Barclays Premier League, there is still a long way to go in that competition, but Jose Mourinho will surely have one eye on a potential league and European double.
Arsenal are out of the UEFA Champions League, having failed to overcome the current holders Bayern Munich in their last-16 tie a week ago.
The Gunners have an FA Cup semi-final against Wigan Athletic to look forward to - and are much-fancied to finally end their nine-year trophy-less run - but will be fully focusing on the league for now.
A solid 1-0 win away at Tottenham Hotspur last week - a vital response to defeat at Stoke City and their European exit - will have helped restore confidence in the ranks.
This means Arsenal can travel to Stamford Bridge without any fear, fancying their chances of securing at least a point this weekend.
BT viewers can watch all the action from Chelsea v Arsenal at 12:45pm on Saturday March 22nd, live on BT Sport 1.