Saracens v Harlequins is one of four Aviva Premiership matches to be broadcast live this weekend, between Friday March 21st and Sunday March 23rd.
The London derby - which is being played on neutral territory at Wembley Stadium - should attract a huge crowd and a large TV audience on BT Sport 1.
Both sides are competing at the right end of the league, with second-placed Sarries a mere two points behind the leaders Northampton, and Quins hovering just outside the end-of-season play-off places in fifth.
Last time out, Saracens saw off Bath 23-10, however Harlequins only just scraped past bottom side Worcester Warriors with a 21-20 victory.
The London derby - which kicks off at 3:15pm - is one of two games to be shown live on BT Sport 1 on Saturday, with London Irish v Bath Rugby following at 5:30pm.
Third-placed Bath will be eager to get back on track following their home defeat to Saracens, and will fancy their chances against an Exiles side which failed to score in an 18-0 loss at Exeter Chiefs.
Irish currently sit tenth in the table, with five wins from 16 games, but they are well clear of bottom place Worcester who look cut adrift and set for relegation.
The Warriors themselves are in action on Friday night this week, with their home game against London Wasps to be shown live on BT Sport 1 at 7:45pm.
Dean Ryan's side have had a three-week break since their last outing - in which they claimed a losing bonus point against Harlequins - and will be ready for the visit of seventh-place Wasps.
It has now been four successive league defeats for Dai Young's men - who have lost to Harlequins, London Irish, Bath and Sale Sharks - so could Worcester finally get that elusive win on the board?
Sunday's televised game sees the current champions Leicester Tigers take on Exeter Chiefs at Welford Road.
The home side sit in fourth place in the table following four successive wins - against Worcester, Gloucester, London Irish and Newcastle Falcons - and they remain unbeaten in the Aviva Premiership in 2014.
Eighth-placed Exeter had lost five in a row prior to their clean-sheet victory against Irish earlier this month, which will have helped boost morale in the Sandy Park camp.