The Barclays Premier League leaders Chelsea take on third-place Manchester United in this weekend's big game live on Sky Sports.
Jose Mourinho's side are seven points clear of their nearest challengers Arsenal with a game in hand, and three points on Saturday April 18th (kick-off 5:30pm) would inch the West London side closer to the title.
However, a Manchester United victory could make things interesting at the top. With Arsenal seemingly unstoppable at the moment, a Blues defeat would create unwelcome pressure at Stamford Bridge.
Three points for the away side would bring United to within five points of their opponents, with Chelsea still to face Arsenal in the league.
Fading Manchester City are also in live action this weekend on Sky Sports. The 2013-14 champions take on West Ham United at the Etihad (kick-off 1:30pm), as they look to stop the rot.
Successive defeats to Crystal Palace and city rivals Man United have seen Manuel Pellegrini's side fall away from the title race.
The Chilean boss looks increasingly under pressure, as he struggles to get the best out of a talented, expensively-assembled City squad, particularly in the big games.
West Ham have fallen off the pace since Christmas, following an excellent first half of the season. But they can still cause any side trouble on their day, and could present another banana skin for Man City.
Straight after the early-afternoon game, Sky Sports subscribers can watch Newcastle United v Tottenham Hotspur at 4pm.
Spurs need three points away at St James' Park as they fight for a European spot for next season, while Newcastle look destined for an underwhelming mid-table finish.
Geordie pride is at stake however; John Carver's side are on a run of five successive Barclays Premier League defeats and have won just once in nine games.