The Manchester derby is one of four live Barclays Premier League games on Sky Sports this weekend.
Manchester United take on the defending champions Manchester City at Old Trafford, in a game which could determine where the two sides finish in the table.
Just one point separates the local rivals, with the Reds on 62 points in third and the Blues on 61 in fourth.
The leaders Chelsea are almost out of sight on 70 points, but second-place Arsenal are still within striking range on 63 points.
And with automatic group spots in the UEFA Champions League up for grabs, each side is eager to secure a top-three placing.
City will be desperate to get Monday's 2-1 defeat to Crystal Palace out of their system, but they are coming up against a United side with five successive wins under their belt.
Louis van Gaal's men are in great form and finally appear to be finding their feet in the post-Sir Alex Ferguson era.
Sky Sports viewers can watch the Manchester derby at 4pm on Sunday April 12th.
There are three other games for subscribers to look forward to, starting with Arsenal's trip to Burnley on Saturday tea-time.
The Gunners head to east Lancashire for this 5:30pm kick-off at Turf Moor, eager to put distance between them and the chasing pack.
Seven wins in a row have seen Arsene Wenger's side shoot up the Barclays Premier League table, meaning they are now Chelsea's closest challengers.
With a game against Jose Mourinho's side coming up later in April, Arsenal could yet put their London rivals under pressure at the top.
Sean Dyche's Burnley are desperate for points - they sit in the relegation zone two points from safety. If the Clarets are to drag themselves out of trouble, their home form will be crucial.
Chelsea are also in action on Sky Sports this weekend; the TV cameras will be at Loftus Road for their clash with QPR.
A win for the league leaders will move them a step closer to the league title, but Chris Ramsey's Hoops side are scrapping for every point at the moment.
With seven games to go, Rangers find themselves third-bottom of the table, two points from safety.
Monday night's game sees Liverpool host Newcastle United at Anfield in an 8pm kick-off.
Things were looking up for Brendan Rodgers' side a few weeks ago, however defeats to Arsenal (4-1) and Man United (2-1) have seen the Reds fall off the pace.
Newcastle's season is pretty much over - the Geordies are nine points clear of relegation and 19 points off the European places.
However, interim boss John Carver is desperate to make a case for his permanent appointment in the summer.